MarketOxa-noribogaine
Company Profile

Oxa-noribogaine

Oxa-noribogaine is an atypical κ-opioid receptor agonist of the "oxa-iboga" family and a synthetic benzofuran analogue of noribogaine. Although it still binds to hERG with similar avidity as noribogaine, it appears to be devoid of the proarrhythmic side effects of noribogaine.

Pharmacology
Pharmacodynamics Oxa-noribogaine acts as an atypical κ-opioid receptor (KOR) partial agonist similarly to noribogaine but shows dramatically increased potency and selectivity compared to noribogaine ( = 43nM vs. 6,100nM, respectively; 142-fold difference). ==History==
History
Oxa-noribogaine was first described in the scientific literature in 2015. Subsequently, it was further described in 2024. ==See also==
tickerdossier.comtickerdossier.substack.com