The primary purpose for which the Refuge was created is its "...particular value in carrying out the national migratory bird management program". The Refuge's interspersion of wetland, forested upland and old field habitats is ideally suited for this purpose. The Refuge supports a diverse mix of migratory birds including waterfowl, wading birds, raptors, shorebirds, passerines, as well as resident mammals, reptiles, amphibians, fish and invertebrates. The extensive and regionally significant wetlands occurring on and adjacent to the Oxbow Refuge, including their associated tributary drainages and headwaters, have been listed as a priority for protection under both the North American Waterfowl Management Plan and the Emergency Wetlands Resources Act of 1986. The portion of the Oxbow NWR south of Route 2 lies within the 12,900-acre Central
Nashua River Valley
Area of Critical Environmental Concern (ACEC) designated by the
Massachusetts Secretary of Environmental Affairs, and the portions of the Refuge north of Route 2 are included in the Squannassit ACEC due to the unique environmental characteristics and values of these wildlife habitats. ==Friends group==