Antonio's architecture and its adoption of Art Deco techniques was radical for its day, neoclassicism being the dominant motif of Philippine architecture when he began his career. His style was noted for its simplicity and clean structural design. He was cited for taking Philippine architecture into a new direction, with "clean lines, plain surfaces, and bold rectangular masses." Antonio strove to make each building unique, avoiding obvious trademarks. Antonio was also conscious of adapting his buildings to the tropical climate of the Philippines. In order to highlight natural light and also avoid rain seepage, he utilized sunscreens, slanted windows and other devices. Antonio himself has been quoted as stating that "
buildings should be planned with austerity in mind and its stability forever as the aim of true architecture, that buildings must be progressive, simple in design but dignified, true to a purpose without resorting to an applied set of aesthetics and should eternally recreate truth" . When he was named
National Artist of the Philippines in 1976, he was only the second architect so honored, after his contemporary,
Juan Nakpil. His eldest son, Architect Pablo Reyes Antonio Jr., restored some of his art deco buildings in the FEU campus. ==Death==