Ramallo (1995–1996) Prigioni began his professional career with Ramallo of the
Argentine LNB League during the 1995–96 season.
Belgrano San Nicolás (1996–1998) Prigioni moved to
Belgrano San Nicolás in 1996, playing with them until 1998.
Obras Sanitarias (1998–1999) Prigioni transferred to
Obras Sanitarias in 1998 and played with the club until 1999.
Fuenlabrada (1999–2001) In 1999, Prigioni moved to the
Spanish club
Fuenlabrada, where he stayed until 2001.
Lucentum Alicante (2001–2003) In 2001, Prigioni joined the Spanish club
Lucentum Alicante, and he played there until 2003.
Baskonia (2003–2009) In 2003, Prigioni joined the
EuroLeague team
Baskonia. With Baskonia he won several titles, including: 3
Spanish King's Cups in the years 2004, 2006, 2009; 4
Spanish Supercups in the years 2005, 2006, 2007, 2008; and the
Spanish League championship in 2008.
Real Madrid (2009–2011) In 2009, Prigioni joined
Real Madrid.
Return to Baskonia (2011–2012) In August 2011, Prigioni returned to Baskonia, signing a one-year deal.
New York Knicks (2012–2015) in 2013 On July 24, 2012, Prigioni signed a one-year contract with the
New York Knicks for the rookie minimum. At age 35, Prigioni became the oldest rookie in
NBA history, when he made his debut on November 2, 2012. He became the team's starting
point guard for the last two months of the 2012–13 season, as well as for the playoffs. In game 6 of the Knicks' first-round playoff series against the
Boston Celtics, Prigioni made 3 three-pointers in the first quarter. The Knicks won 88–80, to advance to the second round of the playoffs for the first time in 13 years. On July 10, 2013, Prigioni re-signed with the Knicks.
Houston Rockets (2015) On February 19, 2015, Prigioni was traded to the
Houston Rockets, in exchange for
Alexey Shved, and two second-round draft picks.
Los Angeles Clippers (2015–2016) On July 20, 2015, the Rockets traded Prigioni,
Joey Dorsey,
Nick Johnson,
Kostas Papanikolaou, a 2016 first-round draft pick, and cash considerations, to the
Denver Nuggets, in exchange for
Ty Lawson and a 2017 second-round draft pick. Prigioni was immediately waived by Denver, upon being acquired. On January 13, 2016, he had a career-high eight steals against the
Miami Heat, which was one shy of the franchise record, held by his head coach,
Doc Rivers. On April 8, 2016, he recorded a season-high 13 points, a career-high seven rebounds, and a season-high seven assists, in a 102–99 overtime win over the
Utah Jazz. On July 29, 2016, Prigioni signed with the Houston Rockets, returning to the franchise for a second stint. However, he was waived by the Rockets on October 24, 2016, after appearing in five preseason games with them.
Third stint with Baskonia (2016–2017) On December 5, 2016, Prigioni returned to Baskonia, signing with them for the rest of the season. He officially retired from his professional basketball playing career on January 9, 2017. During his professional career, Prigioni played in 10 EuroLeague seasons, in which he had career averages of 6.1 points, 4.3 assists, 2.5 rebounds, and 1.7 steals per game, and in four NBA seasons, in which he had career regular season averages of 3.5 points, 2.8 assists, 1.9 rebounds, and 1.0 steals per game. On January 15, 2017, following his retirement, Baskonia retired his jersey number 5. ==Coaching career==