The building was originally built in 1887 as part of two twin neoclassical-style buildings constructed by
Gaetano Koch. It was developed into a luxury hotel in the early 2000s. The new hotel was redesigned by architect Maurizio Papiri and designer Adam D. Tihany. The hotel embraces a wing that was built in 1705 by
Pope Clement XI as a grain store. Some ruins of the
Baths of Diocletian can be seen through glass in the basement. The hotel was one of the Boscolo Hotels chain run by the Boscolo family that once had eight five-star hotels in Europe. In 2011, it became part of the
Autograph Collection by
Marriott. Gruppo Boscolo was acquired in 2017 by
Värde Partners, and the Boscolo Exedra Roma was rebranded as the Palazzo Naiadi (the old name of the square) in April 2018 after being included in the newly launched hotel chain
The Dedica Anthology. In January 2020,
Covivio, a European investment and development company, bought Palazzo Naiadi and seven other hotels of The Dedica Anthology, announcing that Palazzo Naiadi will be a member of the NH Collection, which is managed by
Madrid-headquartered
NH Hotel Group. In 2018,
Minor Hotels, the parent company of
Anantara Hotels & Resorts, acquired a majority stake in NH Hotel Group. Subsequently, several properties under the former Boscolo portfolio are rebranded under the Anantara brand. On June 19, 2013, actor
James Gandolfini died in the hospital after a
heart attack in the hotel. The hotel served as a filming location for the 2021 movie
House of Gucci. ==Hotel==