Palestine High School is a public high school located in Palestine, Texas and classified as a 4A school by the UIL. It is part of the Palestine Independent School District located in central Anderson County. The old Palestine High School built in 1915 is now The Museum for East Texas Culture. During 2023–2024, Palestine High School had an enrollment of 1,016 students and a student to teacher ratio of 12.81. The school received an overall rating of "B" from the Texas Education Agency for the 2024–2025 school year.