The Palisade Hotel is of historic significance for its association with the acquisition, redevelopment and long-term management of large areas around Sydney Harbour by the NSW Government following the outbreak of the bubonic plague in 1900. The hotel is significant having been built by the Sydney Harbour Trust in 1915–16 as one of four hotels provided by the Trust to replace those demolished to provide facilities for port workers and the local community. Stylistically the hotel was built in an era of prodigious hotel building between 1900 and 1914, which ended with the onset of
World War I. Its ongoing use as a hotel since its construction in 1916 with relatively few modifications to layout and fabric further highlights its significance. Its prominent location and continued use demonstrates its significance as part of the social life of Millers Point. The Palisade Hotel is significant having been designed by H. D. Walsh, an engineer important in the history of NSW especially related to developments around Sydney Harbour in the early twentieth century. The hotel is of aesthetic significance as an exceptional example of a federation free style building with arts and crafts influences. Its dramatic form with a very tall and narrow expression is an important contributory feature to the Millers Point townscape resulting in the building being a prominent landmark feature in the area. Its prominent siting provides terminal views along several streets. == Heritage listing ==