PAOK Vasilopoulos began his pro career in 2001, with
PAOK of the
Greek League. He played with PAOK for four seasons, from 2001 to 2005. In the 2005 off season, he transferred from PAOK to joined
Olympiacos Piraeus.
Olympiacos Vasilopoulos was brought to
Olympiacos in 2005, by George Garbolas, on a two-year contract. Garbolas believed in his abilities, and that he could help the team to win championships. On May 20, 2008, he extended his contract with Olympiacos for another 4 years, at a salary of
€6 million
euros net income. With Olympiacos, he won the
EuroLeague and
Greek League championships in 2012.
Injury plagued seasons On February 8, 2012, Vasilopoulos suffered a season-ending leg injury, just after he had returned from a previous back surgery. He was released by
Olympiacos. Vasilopoulos then signed with the
Spanish League club
Valladolid, in September 2013. He was released by Valladolid in December 2013, after suffering a knee injury.
Comeback from injuries After being released by
Valladolid in December 2013, Vasilopoulos then signed with the
amateur level Greek club Ermis Piraeus, in April 2014. He then returned to play
professionally again, in the
Greek top-tier level
GBL, with
Nea Kifissia. Vasilopoulos then moved to the Greek club
Koroivos, for the
2015–16 season. Vasilopoulos next moved to the Greek club
Kolossos Rodou, for the
2016–17 season. On July 26, 2017, Vasilopoulos signed with the Greek club
Aris Thessaloniki, and played with them in the
FIBA Champions League's
2017–18 season.
AEK Athens On January 19, 2018, Vasilopoulos moved to
AEK Athens, for the rest of the season. With AEK, he won the
2018 Final of the
Greek Cup, as well as the
FIBA Champions League championship.
Peristeri On July 27, 2018, Vasilopoulos signed a 2-year contract with
Peristeri of the
Greek Basket League, where he eventually became the
team captain. He averaged 7.1 points, 3.4 rebounds, 1.9 assists and 1.4 steals per game during the 2019-2020 season. On August 17, 2020, he re-signed with Peristeri. On August 20, 2021, he officially parted ways with the club after three seasons and retired from professional basketball. In December 2021, Vasilopoulos joined the coaching staff of
Milan Tomić in
Peristeri. In July 2022, he renewed his contract and stayed on as an assistant to his former national squad and Olympiacos teammate
Vassilis Spanoulis. On June 24, 2023, he parted ways with the club. ==National team career==