From 2011 to 2016, Tramezzani was assistant coach of the
Albania national team, under manager
Gianni De Biasi. On 21 December 2016, he was presented as head coach of
Lugano. In June 2017, Tramezzani was appointed head coach of
Sion before being sacked in October. In October 2018, Tramezzani was appointed as the new manager of
APOEL. He guided them to their seventh
league title after a 3–0 home victory over
Apollon Limassol, and also reached the final of the
Cypriot Cup, where they lost 0–2 to
AEL Limassol. Tramezzani was sacked on 8 August 2019 following a 1–2 loss against
Qarabağ in the first leg of the
UEFA Champions League third qualifying round. On 10 December 2019, he was hired by
Serie B club
Livorno, in last place in the league table at the time. He was dismissed by Livorno on 3 February 2020 after the team only achieved 2 draws and 5 losses in 7 games under Tramezzani's helm. In June 2020, he returned to FC Sion for a second spell as manager of the club. On 18 January 2021, he was appointed by
Hajduk Split as head coach. He finished the
season in fourth place, taking Hajduk to the
Europa Conference League second qualifying round, before leaving the club on 27 May by mutual consent. On 18 June 2021, Tramezzani was appointed as the manager of Saudi Arabian club
Al-Faisaly. He successively signed for
Swiss Super League club
FC Sion, being later replaced by
Fabio Celestini on 21 November 2022. Following a five game win drought and a humiliating 2–7 defeat at home to
FC St. Gallen on 12 November 2022, he was terminated on 20 November 2022. On 16 May 2023, he was once again appointed as head coach of Sion, as he was still under contract. He coached the final games of the season, including the
relegation play-off, which saw Sion relegated from the Super League. On 8 February 2024, Tramezzani returned to Croatia, becoming the coach of
Croatian Football League team
Istra 1961. He returns to the Swiss Super League on 28 December 2024, after being appointed as the new head coach of
Yverdon-Sport FC. On July 2025, Tramezzani was appointed as the manager of Cyprian club
AEL Limassol, but in november was sacked. ==Managerial statistics==