Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the
protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular
amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by
thrombin and
trypsin. ==See also==