Humphreys opened his practice in
Nashville, Tennessee, a major city in Middle Tennessee. He became politically active and was elected to the
Tennessee House of Representatives in 1805 and the
Tennessee Senate in 1807. He served as a justice of the
Supreme Court of Tennessee from 1807 to 1809, and a judge of the State judicial circuit from 1809 to 1813. Elected as a
Democratic-Republican to the
Thirteenth Congress, Humphreys served one term from March 4, 1813 to March 3, 1815. In 1817 he was an unsuccessful candidate for the
United States Senate. Following that, he gained another judicial appointment. He served as a judge on the State judicial circuit for nearly two decades, from 1818 to 1836. Humphreys moved to
Hernando, Mississippi. There he engaged in
banking until his death. ==Personal life, death and legacy==