Pathologic fracture

Pathologic fractures in children and adolescents can result from a diverse array of disorders namely; metabolic, endocrine, neoplastic, infectious, immunologic, and genetic skeletal dysplasias. • Primary hyperparathyroidism • Simple bone cyst • Aneurismal bone cyst • Osteoporosis • Chronic osteomyelitis • Osteogenesis imperfecta • Osteomalacia • Rickets • Renal osteodystrophy • Malignant infantile osteopetrosis • juvenile osteoporosis • juvenile rheumatoid arthritis Miscellaneous causes • Monostotic fibrous dysplasia • Eosinophilic granuloma • Bone atrophy secondary to diseases like polio ==Diagnosis==

The underlying cause of the pathological fracture should always be found, to guide the optimal treatment path. If the cause is unknown, a thorough workup should be performed, including laboratory tests and radiological examinations - often magnetic resonance imaging of the affected area as well as computed tomography of the chest, abdomen and pelvis (for staging or identifying a primary malignancy). Often, a biopsy from the fracture site is taken to obtain a histopathological or cytological diagnosis. A common method of initial biopsy is a Fine Needle Aspiration Cytology (FNAC). In circumstances where other pathologies are excluded (for example, cancer), postmenopausal women or men aged >50 years who present with a hip fracture after a low-energy fall can be diagnosed with osteoporosis irrespective of bone mineral density, and offered treatment. Diagnosis can also be made ff a previous fragility fracture of the pelvis, vertebra, wrist or proximal humerus is present in combination with osteopenia. ==Management==

Once a fracture has occurred, intramedullary fixation is the usual surgical management for certain long bones, such as the femur, tibia, and fibula. However, the method of fixation should depend on several factors; The fracture location, underlying cause, prognosis of the underlying cause and patient activity level. Fracture healing potential is also different for different malignancies, which needs to be taken into account. For example, if the patients' life expectancy is long, fixation needs to be stronger to account for reduced healing potential, which could be an argument for total replacement of the fractured area with a prosthesis instead of internal fixation (which is dependent on fracture healing). On the other hand, in case of a patient with poor prognosis or low activity level, a minimally invasive internal fixation could be enough to improve quality of life - in this case the patient is either not expected to survive long enough for the fixation to fail, or are not active enough for reduced healing potential to become a problem. Several scoring systems exist to help in the evaluation of impending pathological fractures (where a pathological process has weakened the bone but not yet caused a fracture). The most commonly used are Mirel's score (for metastatic disease in long bones) and Harrington's score (for metastatic disease in the proximal femur) . For both instruments, a higher score means a higher risk of fracture, based on similar criteria; fracture location, patient symptoms, size of lesion, and type of lesion. Based on Mirel's score (if the score is more than 8), bone fixation should be done prophylactically. Fixation is done by internal fixation rather than conservatively, along with treatment of the underlying cause. == References ==