Ryan was ordained to the
priesthood by Archbishop
Peter Richard Kenrick on September 8, 1853. At age 21, he was below the age requirement for ordination but was granted a
dispensation by
Pope Pius IX. He was then appointed an assistant
rector at the
Cathedral of St. Louis, and was advanced to rector in 1856. In 1860, he was named
pastor of the Church of the Annunciation in
St. Louis, where he built a
church and
parochial school. During the
Civil War, he served as a
chaplain for prisoners of war at the
Gratiot Street Prison. In the same parish was a government military hospital. Every day Ryan visited the Confederate prisoners and the Union wounded. Following the war, he was transferred to St. John's Church in St. Louis, and accompanied Archbishop Kenrick, as theologian, to the
Second Plenary Council of Baltimore in 1866. While on a visit to
Europe in 1868, he delivered the
English course of
Lenten lectures in
Rome at the invitation of Pius IX. ==Episcopacy==