De Vos was born in Hulst near Antwerp, now in the Dutch province of
Zeeland. Little is known of his childhood. His father moved with his family to Antwerp in 1596. In 1604 Paul de Vos became a pupil of the obscure painter Denijs van Hove in Antwerp. In 1605 he continued his studies under the little-known painter
David Remeeus (1559–1626) with whom his older brother
Cornelis also trained. He later also trained with the equally obscure Eduard Snayers. De Vos became a master and joined the
guild of St. Luke at a late age in 1620, probably because he had initially trained and worked in the workshop of his brother-in-law
Frans Snyders who had married his sister Margaretha in 1611. Paul de Vos married Isabella Waerbeek, a notary's daughter, on 15 Nov 1624 and the couple had 10 children. In 1637-1638 he worked on the decorations for the Spanish royal residences,
Buen Retiro and
Torre de la Parada. Most of the decorations at the Torre de la Parada involving animal scenes without humans were by his hand. The governor of the Governor of the Spanish Netherlands
Cardinal-Infante Ferdinand visited his workshop. He had two pupils: Alex Daemps in 1627 and Lancelot van Daelen in 1636. ==Work==