Oscher met Muddy Waters in the mid-1960s. After
Big Walter Horton failed to show up for a gig, Oscher played harmonica as a member of the Muddy Waters Blues Band from 1967 until 1972. He was the first white musician in Muddy's band, and lived in Muddy's house on Chicago's
South Side, where Oscher shared the basement with the blues pianist
Otis Spann. Oscher recorded with Muddy for
Chess Records. After performing solo for a time in New York as "Brooklyn Slim", he toured Europe in 1976 with
Louisiana Red. They both appeared at the WDR-TV music show,
Rockpalast. During the 1990s, Oscher worked as a multi-instrumentalist, playing piano, guitar and harmonica, sometimes as a
one-man band. He recorded an album in 1995,
The Deep Blues of Paul Oscher. In 1999, he played with
Big Bill Morganfield on his debut album,
Rising Son. In 2003, Oscher was featured on harmonica, guitar and vocals on
Hubert Sumlin's album,
About Them Shoes, along with
Keith Richards,
Eric Clapton and
Levon Helm. In 2006, Oscher collaborated with
Mos Def and recorded the song, "Bed Stuy Parade and Funeral March", on Mos Def's album,
The New Danger. In 2008, he recorded with
Keb' Mo' on the soundtrack of a film about the blues,
Who Do You Love?. ==Personal life and death==