Prudhomme opened his first restaurant in Opelousas in 1957, a hamburger restaurant called Big Daddy O's Patio. The restaurant went out of business in nine months, during which time his first marriage also ended. under
Richard Brennan, Sr. The restaurant was named as a
portmanteau of their names, with Paul working as head chef and Kay as restaurant manager. For a while he attempted to operate the restaurant while still working at
Commander's Palace, but the demand in his new restaurant was such that he moved to work there full-time, while also appointing
Emeril Lagasse to take over as executive chef at Commanders Palace. Prudhomme has been credited with having popularized
cajun cuisine and in particular
blackened redfish during the 1980s. The popularity of the fish was such that commercial fishing of the species was restricted to prevent its extinction. During a summer residence in
New York City in 1985, Prudhomme's
pop-up restaurant was reported to the Board of Health, which visited the restaurant and closed it before it opened, reporting 29 violations of the city's health code. resulting in the Board of Health threatening him with jail time if he continued to operate the restaurant. The
city's mayor Ed Koch appeared with Prudhomme at the restaurant to declare an end to what the media reported as the "gumbo war". The restaurant was quite successful during the five weeks it was open, with lines sometimes reaching four blocks long. Four years later, Prudhomme opened a permanent restaurant in New York City at 622 Broadway, which had queues of up to two hours. He made a guest appearance at
Le Cordon Bleu cooking school in
Paris, France, in October 1994. In 2004, he traveled to
Guantanamo Bay Naval Base in Cuba, along with of food and seasonings to cook for the troops stationed there. Following
Hurricane Katrina in August 2005, Prudhomme was forced to close his restaurant. During the restoration efforts, he cooked for free at a relief center for the military and residents staying in the French Quarter; at one point his team cooked over 6,000 meals in ten days. He reopened the restaurant during the following October; the premises were not extensively damaged by the storm.
Bon Appétit awarded Prudhomme their Humanitarian Award in 2006 for his efforts following the hurricane. ==Product lines==