The ENIGMA Consortium, co-founded by Thompson, performs some of the largest-ever studies of the
human brain, analyzing brain scans of more than 50,000 people worldwide. This collaborative group studies 22
brain diseases in 37 countries, focusing on the interaction between brain health and genetics. ENIGMA has published some of the largest-ever neuroimaging studies of
schizophrenia, major depression,
bipolar disorder,
epilepsy,
autism spectrum disorder, and
obsessive–compulsive disorder. In 2020, Thompson launched AI4AD, a consortium of researchers across the United States that aims to develop AI tools to analyze and integrate genetic, imaging and cognitive data relating to Alzheimer’s disease. In 2023, Thompson launched the India ENIGMA Initiative, a study of factors that affect brain aging and mental health in India. == Academic career ==