A penetrating head injury, or open head injury, is a head injury in which, at minimum the dura mater — the outer layer of the meninges — is breached. Penetrating injuries can be caused by high-velocity projectiles or objects of lower velocity such as knives, or bone fragments from a skull fracture that are driven into the brain. Head injuries caused by penetrating trauma are serious medical emergencies and frequently cause irreversable brain damage, permanent disability, or death.