Somerset County PA 160 begins at the
Maryland border in the borough of
Wellersburg in Somerset County, where the road continues south into that state as
MD 47. From the state line, the route heads north-northwest on two-lane undivided Main Street, passing through wooded areas of homes. The road turns north and enters
Southampton Township, becoming Cumberland Highway and heading through forested areas with some residences. PA 160 curves northwest and heads west through more wooded areas with some fields and homes, passing through Pleasant Union. The road continues into
Larimer Township and turns northwest into open agricultural areas with some woods and residences, forming the border between Larimer Township to the southwest and the borough of
Callimont to the northeast again before fully entering Larimer Township again and passing southwest of Wittenberg. The route forms the border between Larimer Township and Callimont on two more occasions before heading into more forested areas of Larimer Township and passes over the Sand Patch Tunnel carrying
CSX's
Keystone Subdivision railroad line. PA 160 turns north-northeast and runs through woods with some fields and homes, passing through
Northampton Township before heading north into
Brothersvalley Township. The road heads through farmland with some woodland and residences, reaching the borough of
Berlin. At this point, the route becomes Cumberland Street, passing homes and turning northeast onto Main Street. PA 160 curves east and passes through more residential areas before turning northeast onto Huckleberry Highway and crossing back into Brothersvalley Township. The road heads through open agricultural areas with some woodland and homes, coming to an intersection with
PA 31 in
Roxbury. This route then crosses into
Stonycreek Township and continues through more rural areas, running through Downey and passing under
I-70/
I-76 (
Pennsylvania Turnpike). PA 160 heads north-northeast through more farmland and woodland with some homes, passing through Glade. The road passes to the east of the borough of
Indian Lake prior to coming to an intersection with
US 30 in Reels Corners, at which point it crosses into
Shade Township. Here, the route becomes Rock Cut Road and heads north through wooded areas with some residences, curving to the north-northeast. PA 160 turns to the east and enters the borough of
Central City, becoming Lambert Street and heading east past homes. The route turns north onto Central Avenue before turning northeast onto Sunshine Avenue and crossing
Norfolk Southern's South Fork Secondary railroad line as it heads into the commercial downtown of Central City. PA 160 turns northwest onto Main Street and passes through more residential areas before crossing back into Shade Township. The route continues back into Summerhill Township and runs northeast through farms and woods with some homes before heading north into forested areas. PA 160 heads into
Cambria Township and becomes Wilmore Road, turning west onto Fairlane Road and heading through more woods with some homes, curving to the west-northwest. The route turns northeast onto New Germany Road and runs through more woodland with some fields and development, curving to the north. PA 160 heads into residential areas and turns northeast, passing to the southeast of the Ebensburg Center. The road passes under
US 22 and becomes the border between Cambria Township to the west and the borough of
Ebensburg to the east, turning north. PA 160 comes to its northern terminus at an intersection with SR 4031 (West High Street). ==Major intersections==