Fayette County on the
Ohiopyle Highway Bridge PA 381 begins at the
West Virginia border in
Wharton Township,
Fayette County, where the road continues south into that state as CR 8 in
Preston County. From the state line, the route heads north on two-lane undivided Wharton Furnace Road, passing through woodland with some farms and homes as it runs through tracts of the
Forbes State Forest. PA 381 runs through more rural areas and reaches Elliottsville, where it turns southeast onto Elliottsville Road. The road curves to the east and heads through more forests before turning northeast into a mix of farmland and woodland with a few residences. The route continues north and north-northeast and reaches an intersection with
US 40 in
Farmington. Prior to a realignment in 2017, PA 381 briefly turned southeast to form a
concurrency with US 40 due to an offset intersection which was eliminated. North of US 40, PA 381 runs through more forested areas with some fields and homes, crossing into
Stewart Township. The road heads through more rural areas, crossing into forested
Ohiopyle State Park. The route continues through the park and becomes Main Street as it heads into the borough of
Ohiopyle and crosses Meadow Run. PA 381 passes a few homes prior to crossing the
Youghiogheny River on the
Ohiopyle Highway Bridge and becoming Mill Run Road, crossing
CSX's
Keystone Subdivision railroad line. The road heads back into forested areas of Ohiopyle State Park and turns northeast, crossing back into Stewart Township. The route curves east and leaves the state park as it heads north through wooded areas of homes before passing through an agricultural clearing. PA 381 runs through more forested areas and passes through Kauffman, at which point it heads to the east of
Fallingwater, a house designed by architect
Frank Lloyd Wright. The road continues through forests with some farm fields and homes, heading into
Springfield Township at the point it crosses Laurel Run. The route heads north into open agricultural areas with some woods and residences, passing through
Mill Run. PA 381 runs through more farmland and woodland with some homes, crossing
Indian Creek to the east of Indian Creek Reservoir. The road becomes Whites Bridge Road and intersects the western terminus of
PA 653 before curving northwest and coming to a junction with
PA 711 near
Normalville. At this point, the route turns northeast to form a concurrency with PA 711 on Indian Creek Valley Road, continuing through wooded areas with some farm fields and residences. The road crosses into
Saltlick Township and passes through
Frogtown, at which point it runs a short distance to the northwest of Indian Creek. The two routes curve north and wind northwest through more rural areas, passing through
Sagamore and Davistown. PA 381/PA 711 turns northeast and runs through more farmland and woodland with homes, going through
Melcroft and Coffman, turning north again. ==Major intersections==