PA 449 begins at an intersection with
US 6 in the community of Walton in
Ulysses Township, heading northwest on Brookland Road parallel to the
Pine Creek. The road heads through forested mountains in the
Susquehannock State Forest before coming to the community of Brookland, where it crosses the creek twice in quick succession. After passing through more forests, the route enters agricultural areas and becomes Gold Road, crossing the
Genesee River and intersecting
PA 49 in the community of
Gold. From this point, PA 449 turns north and continues through a mix of farmland and woodland in a narrow valley parallel to the Genesee River. The road briefly enters
Allegany Township before heading into
Genesee Township and passing through the community of Harmontown. The route runs through more rural areas before intersecting
PA 244 in the community of
Genesee. PA 244 formed a concurrency through Genesee on Main Street from 2003 until 2011 while the School Street Bridge was closed. Through Genesee, the road passes homes and businesses, briefly becoming a two-lane
divided highway before the intersection with Commercial Street. At this intersection, PA 449 turns to the west and heads northwest out of Genesee on two-lane undivided North Genesee Street into a mix of farms, woods, and homes. PA 449 ends at the
New York border, where the road becomes
NY 19. ==Major intersections==