PA 722 begins at an interchange with the
PA 283 freeway in
East Hempfield Township,
Lancaster County, heading north on two-lane undivided State Road. South of this interchange, State Road continues as a local road. From PA 283, the route passes a couple businesses before heading into agricultural areas, turning to the east. The road crosses
Norfolk Southern's Lititz Secondary railroad line at-grade and enters the borough of
East Petersburg, where the name becomes State Street. PA 722 heads northeast through residential areas with some businesses, curving to the east and intersecting Lemon Street. A block later, the route crosses
PA 72 in the center of East Petersburg. The road continues past homes and becomes Cottage Avenue, curving to the north and then to the northeast. PA 722 crosses the
Little Conestoga Creek into
Manheim Township and becomes Petersburg Road, winding east through suburban residential areas with some businesses and crossing
Fruitville Pike. The route heads through Groffs Corner and passes to the south of a farm before turning southeast past more homes and reaching a junction with
PA 501 in
Neffsville. At this point, PA 722 turns north to form a
concurrency with PA 501 on Lititz Pike, passing through suburban development. PA 722 splits from PA 501 by heading east along East Oregon Road, running through suburban neighborhoods. The road turns north and heads into industrial areas, where it bends east. The route continues through agricultural areas with a couple residential subdivisions to the south of the road. Farther east, PA 722 passes through the residential community of
Oregon and crosses Lititz Run before it reaches its eastern terminus at an intersection with
PA 272. ==History==