PA 764 begins in
Allegheny Township at an interchange with
US 22, south of downtown
Altoona. The junction is composed of two
trumpet-style interchanges connecting PA 764 with the US 22 freeway. To the south of the interchange, the surface road continues as US 22 to Duncansville. From there, PA 764 is aligned north–south through the southern Altoona suburbs and small hamlets, running parallel to and west of I-99/US 220. Upon entering the city, PA 764 becomes 6th Avenue and begins intersecting numbered streets, starting with 58th Street and decreasing to lower numbers as one moves north. Approaching the downtown area, PA 764 splits into the 6th and 7th Avenue
one-way pair and enters the commercial district of Altoona. 6th Avenue is mostly the boundary between the downtown and Dutch Hill (except near the school zones). The two pairs intersect Union Avenue (
PA 36) near the heart of the city, around the edge of the downtown. The PA 764 one-way couple remains parallel and separate for , into the northern portions of Altoona. In the northern section of the city, the two pairs merge and turn right onto Lloyd Street, while Sixth Avenue Road continues to the north. PA 764 runs east on Lloyd Street for eight blocks, then turns north to become Walton Avenue. Outside of Altoona, PA 764 merges onto
US 220 Business, to begin a long overlap with the route on Pleasant Valley Boulevard. ==History==