Pentagalloylglucose

Pentagalloylglucose can be found in Punica granatum (pomegranate), Elaeocarpus sylvestris, Paeonia suffruticosa (Tree Peony), Mangifera indica (mango) and Bouea macrophylla Griffith (maprang). == Biosynthesis ==

The enzyme beta-glucogallin-tetrakisgalloylglucose O-galloyltransferase uses 1-O-galloyl-β-D-glucose and 1,2,3,6-tetrakis-O-galloyl-β-D-glucose to produce D-glucose and pentagalloylglucose. == Metabolism ==

Tellimagrandin II is formed from pentagalloylglucose by oxidative dehydrogenation and coupling of 2 galloyl groups. β-glucogallin: 1,2,3,4,6-pentagalloyl-β-D-glucose galloyltransferase is an enzyme found in the leaves of Rhus typhina that catalyzes the galloylation of 1,2,3,4,6-penta-O-galloyl-β-D-glucose to 3-O-digalloyl-1,2,4,6-tetra-O-galloyl-β-D-glucose (hexagalloylglucose). == Chemistry ==

Pentagalloylglucose can undergo oxidation reactions which are depending on the pH. ==Research==

Pentagalloylglucose has been studied for its potential use as an antimicrobial, anti-inflammatory, anticarcinogenic, antidiabetic, and antioxidant. It has also been studied for radioprotection. This compound helps stabilize the elastin and collagen in vascular tissues and restores the biomechanical properties of arterial ECM. In addition, pentagalloylglucose has shown to reduce arterial calcification and helps promote extracellular matrix preservation in animal models of abdominal aortic aneurysm. In vitro studies with mouse C2C12 myoblast cells have shown the PGG helps in lowering reactive oxygen species (ROS) and matrix metalloproteinase-2 (MMP-2) expression in a dose-dependent manner. == References ==