A pentavalent vaccine combines five vaccines into one dose. Some pentavalent vaccines are:DTwP-HepB-Hib vaccine, which protects against diphtheria, tetanus, whooping cough, hepatitis B and Haemophilus influenzae type B and is generally used in middle- and low-income countries. DTaP-IPV/Hib vaccine, used in the UK until 2017. DTaP-IPV-HepB vaccine, approved in the US.