Weiss stood as a candidate in the 2019 European parliamentary election for the
Conservative People's Party. She was first on her
party's list. Weiss was elected as its sole MEP in
Denmark. In the
European Parliament, Weiss is part of the
European People's Party Group. In addition to her committee assignments, Weiss is part of the delegation to the
ACP–EU Joint Parliamentary Assembly. She is also a member of the European Parliament Intergroup on Climate Change, Biodiversity and Sustainable Development, the European Parliament Intergroup on Small and Medium-Sized Enterprises (SMEs), the
European Parliament Intergroup on LGBT Rights and the MEP Interest Group on Obesity & Health System Resilience. In May 2023, an internal investigation uncovered reports of bullying in Weiss’ office. Shortly after, the Conservative People's Party under its leader
Søren Pape Poulsen announced that it would not nominate her as a candidate for the
2024 European Parliament election. ==Political positions==