Rost worked at medical advertising agencies prior to working for pharmaceutical companies. Rost started working at
Wyeth in approximately 1992; seven years after joining Wyeth, he was promoted to head of Wyeth-Lederle Nordiska, Wyeth's Scandinavian subsidiary. Rost has said that he doubled sales during his tenure. He became concerned about Wyeth's accounting practices and informed upper management of his concerns. Shortly thereafter, he was transferred from Sweden to New Jersey, a move he characterized as a retaliatory demotion. He filed a lawsuit against Wyeth, which was settled out of court for undisclosed terms. Rost left Wyeth for
Pharmacia in June 2001 and took a role leading its endocrinology division, and said that he soon began to be concerned from a business perspective about sales of Genotropin, Pfizer's
human growth hormone drug, which had plateaued; Pharmacia's decision to pour money into
off-label marketing to adults was not paying off, due to the low doses that adults took. In the next year, Rost became aware that the strategy was not only unwise, but was probably illegal, and began raising objections internally to try to get the company to change course. The review was noticed by a reporter at
USA Today, which interviewed him for an article on the drug industry. The public spotlight from the
USA Today article "changed Rost's life" and launched his new career as an insider critical of the drug industry. In September 2004, Rost testified at a Congressional hearing over the reimportation of drugs, in which he stated that "Holding up a vote on importation, stopping good importation bills has a high, high cost not just in money, but in American lives. Every day we delay, Americans die because they cannot afford life-saving drugs." Pfizer responded by sending a letter to Congress that said, "Dr. Rost has no qualifications to speak on importation, no responsibilities in this area at Pfizer, no knowledge of the information and analysis Pfizer has provided to the government on this issue, and no substantive grasp of how importation may impact the safety of this nation's drug supply." Rost followed up that testimony with an opinion piece published by
The New York Times. In mid-2005, Rost appeared on a
60 Minutes segment about drug pricing. In late 2005, Rost's lawsuit against Pfizer under the
False Claims Act was unsealed (see below) and in December 2005, Pfizer fired him. At Pfizer, Rost had made $600,000 per year for "by his own account, doing essentially no work". In September 2006, Rost's book,
The Whistleblower, Confessions of a Healthcare Hitman, was published, which described his tenure at Pharmacia and Pfizer and his efforts to deal with the marketing of Genotropin. and a column for
Realtid, a Swedish online business newspaper. Later in 2007, Rost announced his new business venture, as a Pharmaceutical Marketing Expert Witness. Rost was featured in the award-winning documentary film
Fire in the Blood in 2013. ==Litigation==