This gene is a homolog of the
Drosophila polyhomeotic gene, which is a member of the
Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein
BMI1. The gene product, the EDR2 protein, and the
Drosophila polyhomeotic protein share two highly conserved domains, named homology domains I and II. These domains are involved in
protein–protein interactions and may mediate
heterodimerization of the protein encoded by this gene and the EDR2 protein. == Interactions ==