Drucker's early career encompassed both classical theatre pieces like
Le Misanthrope, and contemporary plays such as
Blanc by Emmanuelle Marie. Drucker has been twice nominated for the
Molière Award for Best Female Revelation, in 2001 for her role in
Danny et la grande bleue and in 2004 for
84 Charing Cross Road. In 2019, Drucker began her first work in English-language television, starring as Catherine Durand in three seasons (24 episodes) of the
StudioCanal French-British television series
War of the Worlds (2019–2022), alongside
Gabriel Byrne and
Daisy Edgar-Jones. In 2025, Drucker starred in
Dominik Moll's
crime drama Case 137, which premiered in competition at the
78th Cannes Film Festival. For her performance, she won her second
César Award for Best Actress, ==Personal life==