P. adiposa produces many bioactive compounds that are of interest for potential medicinal properties. These include
methyl gallate,
Angiotensin 1-converting Enzyme (ACE) inhibitory peptide, and various polysaccharides with antitumor and antioxidant properties. The purported health benefits of this fungus has generated interest in improving the yields of commercially cultivated
P. adiposa.
Methyl gallate P. adiposa is the first fungus from which methyl gallate has been extracted. Methyl gallate has been studied for its antioxidant and related treatment properties. Antioxidants isolated from natural sources are desired due to their generally low cytotoxicity. Methyl Gallate was shown to preferentially scavenge superoxide (O2-) ions, which have been hypothesized to be involved in
HIV-LTR activation.
Polysaccharides Various
polysaccharides isolated from
P. adiposa have been shown to have anti tumor effects in mice. One dubbed SPAP2-1 interfered with the cell cycle and induced apoptosis in
HeLa cells. Another called PAP-1a was combined with gold
nanoparticles, increasing the
macrophage count in mice. Other polysaccharides have been isolated which exhibit antioxidant effects. An overview of the literature on
P. adiposa polysaccharides has suggested their antitumor abilities are closely tied to their antioxidant abilities. == See also ==