Opoku-Gyimah joined the civil service working for the Department for Work and Pensions benefit fraud section. She is a co-founder, trustee and executive director of
UK Black Pride, which "promotes unity and co-operation among all Black people of African, Asian, Caribbean, Middle Eastern and Latin American descent, as well as their friends and families, who identify as lesbian, gay, bisexual or transgender". Opoku-Gyimah was appointed trustee of lesbian, gay, bisexual and transgender (LGBT) rights charity,
Stonewall in January 2015 but resigned three years later when the charity announced it would partner with
UK Black Pride. Opoku-Gyimah publicly
refused an MBE in the
2016 New Year Honours. With
Rikki Beadle-Blair and
John R Gordon, she is the editor of
Sista!, an anthology of writings by LGBT women of African/Caribbean descent with a connection to the United Kingdom, released by Team Angelica Publishing in 2018, which includes work by 31 writers, including
Yrsa Daley-Ward and Babirye Bukilwa. Well known among the trade union movement, she served on the
Trades Union Congress (TUC) race relations committee and was head of equality at the
Public and Commercial Services Union until June 2019. In May 2019, Opoku-Gyimah was appointed executive director human rights charity the
Kaleidoscope Trust. She later resigned in November 2023, to become the first chief executive of the charity she founded
UK Black Pride. Opoku-Gymiah has been a member of
Sky’s diversity and inclusion advisory council since July 2023. In June 2025, she was refused a rightful entry in the USA without a visa because she had previously visited
Cuba, thus compromising her
ESTA. == Political activity ==