Flavones

The estimated daily intake of flavones is about 2 mg per day. ==Drug interactions==

Flavones have effects on CYP (P450) activity, which are enzymes that metabolize most drugs in the body. ==Biosynthesis==

The biosynthesis of flavones proceeds from the phenylpropanoid pathway, which uses L-phenylalanine as a starting point. Phenylalanine ammonia lyase facilitates the deamination of L-phenylalanine to (E)-cinnamate, Coenzyme A is attached to the carboxylate facilitated by 4-Coumarate-CoA ligase, forming (Coumaroyl-CoA). which is subsequently isomerized by chalcone isomerase resulting in a flavanone (naringenin is shown). It is at this point that the flavanone can undergo further modifications (such as glycosylation or methylation at the various points of the backbone. The subsequent modified flavanones are then transformed into flavones by flavone synthase, which generates a double bond between the C-2 and C-3 positions (the synthesis of apigenin is shown). ==Organic chemistry==

In organic chemistry several methods exist for the synthesis of flavones: • Allan–Robinson reaction • Auwers synthesis • Baker–Venkataraman rearrangement • Algar–Flynn–Oyamada reaction Another method is the dehydrative cyclization of certain 1,3-diaryl diketones. Wessely–Moser rearrangement The Wessely–Moser rearrangement (1930) has been an important tool in structure elucidation of flavonoids. It involves the conversion of 5,7,8-trimethoxyflavone into 5,6,7-trihydroxyflavone on hydrolysis of the methoxy groups to phenol groups. It also has synthetic potential for example: This rearrangement reaction takes place in several steps: A ring opening to the diketone, B bond rotation with formation of a favorable acetylacetone-like phenyl-ketone interaction and C hydrolysis of two methoxy groups and ring closure. == Common flavones ==

In one preliminary 2021 study, flavone intake was associated with lower odds of subjective cognitive decline after adjustment for age, total energy intake, major nondietary factors, and specific dietary factors. ==References==