Main •
Hailee Steinfeld as
Violet / "Vi", a Zaunite orphan and Jinx's sister •
Ella Purnell as
Powder / Jinx, a Zaunite orphan and Vi's sister •
Mia Sinclair Jenness as young Powder •
Kevin Alejandro as Jayce Talis, a scientist, inventor, and eventual member of the Piltover council, who is responsible for the creation of Hextech • Faustino Duran as young Jayce Talis •
Katie Leung as Caitlyn Kiramman, a Piltover enforcer and Jayce's former lab assistant, who becomes Vi's love interest • Molly Harris as young Caitlyn Kiramman •
Jason Spisak as Silco, a crime lord based in Zaun, Jinx's second adoptive father, and leader of the Chem-Barons •
Toks Olagundoye as Mel Medarda, a member of the Piltover council who takes an interest in Jayce and Viktor's experiments, and later begins a relationship with the former. She is the disowned heir of Ambessa Medarda and becomes entangled in a conspiracy with the Black Rose. •
Imogen Faires as young Mel Medarda •
Harry Lloyd as Viktor, Jayce's research partner and former assistant to Cecil B. Heimerdinger, who helped Jayce in the creation of Hextech. He grows to become obsessed with using magic to perfect humanity, partly due to his physical disabilities. Viktor is originally from Zaun, but lives in Piltover. •
Edan Hayhurst as young Viktor •
JB Blanc as Vander, Silco's former brother-in-arms who took part in a rebellion that led to the death of Vi and Jinx's parents, leading him to adopt both of them. He is also the owner of The Last Drop bar. In the second season, he is turned into a wolf-like beast named Warwick by Singed. • Blanc also voices Irius Bolbok (season 1), a member of the Piltover council • Reed Shannon as Ekko, a childhood friend of Vi and Jinx, and the leader of the revolutionary Zaunite group, the Firelights •
Miles Brown as young Ekko •
Mick Wingert as Cecil B. Heimerdinger, a founder of Piltover and leader of the city's council who mentors Jayce, Viktor, and later Ekko • Wingert also voices Heenot (season 2), an accountant who works for the Chem-Barons •
Amirah Vann as Sevika, Silco's right-hand woman and chief enforcer •
Ellen Thomas as Ambessa Medarda, Mel's mother and a respected but brutal war general from Noxus who seeks to use Hextech weapons against the Black Rose •
Brett Tucker as Dr. Corin Reveck / Singed, Viktor's former mentor, and the chief scientist for Silco and later Ambessa, who performs unethical experiments in an effort to realize immortality and save his cryopreserved daughter
Recurring •
Shohreh Aghdashloo as Grayson (season 1), the original sheriff of Piltover •
Remy Hii as: • Marcus (season 1), the sheriff of Piltover who is secretly a corrupt enforcer working for Silco • Tobias Kiramman, Caitlyn's father •
Josh Keaton as: • Deckard (season 1), a Zaunite thug who works for Silco • Allira Salo, a member of the Piltover council with selfish interests •
Bill Lobley as Huck, a resident of Zaun who becomes addicted to shimmer •
Yuri Lowenthal as Mylo, Vi and Jinx's arrogant adoptive brother •
Roger Craig Smith as Claggor, Vi and Jinx's strong adoptive brother •
Fred Tatasciore as Benzo, Ekko's adoptive father, Vander's friend, and a pawn shop owner • Mara Junot as Shoola, a member of the Piltover council •
Erica Lindbeck as Elora, Mel's assistant • Abigail Marlowe as: • Cassandra Kiramman, Caitlyn's mother and a member of the Piltover council • Renni, a Chem-Baron who runs several chemical facilities •
Dave B. Mitchell as Torman Hoskel (season 1), a member of the Piltover council •
Kimberly Brooks as: • Sky Young, Viktor's assistant who has an unrequited crush on him • Margot (season 2; mute in season 1), a Chem-Baron who provides prostitution services •
Miyavi as Finn (season 1), a Chem-Baron who supplies weaponry and seeks to usurp Silco • Stewart Scudamore as Rictus (season 2; mute in season 1), Ambessa's bodyguard •
Earl Baylon as Loris (season 2), a Piltover enforcer who befriends Vi and joins Caitlyn's strike team • Katy Townsend as Maddie Nolen (season 2), a Piltover enforcer who befriends Caitlyn and joins her strike team • Lucy Lowe as Isha (season 2), a Zaunite orphan adopted by Jinx •
Ashley Holliday as Gert (season 2), a prominent member of the Jinxers resistance group •
Minnie Driver as LeBlanc / the Illusionary Sorceress (season 2), the leader of the Black Rose who is at odds with Ambessa
Guest •
Imagine Dragons as The Last Drop's band (season 1) •
JID as The Last Drop's rapper (season 1) •
Ray Chen as an orchestra concert soloist (season 1) • Krizia Bajos as Ximena Talis (season 1; mute in season 2), Jayce's mother who was rescued by a mysterious wizard in her past •
Mira Furlan as Babette (season 1; mute in season 2), the madame of a brothel in Zaun •
Salli Saffioti as Amara, a member of Piltover's merchant guild who is secretly a member of the Black Rose •
Robbie Daymond as Scar (season 2; mute in season 1), Ekko's right-hand man and second-in-command of the Firelights • Lenny Citrano as Smeech (season 2; mute in season 1), a Chem-Baron who sells cybernetic enhancements •
Lex Lang as Chross (season 2; mute in season 1), an elderly Chem-Baron who runs a network of informants •
Eve Lindley as Lest (season 2), a healer working for Salo who also spies on him for Mel • Keston John as Kino Medarda (season 2), Mel's deceased older brother •
Jeannie Tirado as Felicia (season 2), Vi and Jinx's deceased mother The
League of Legends character Orianna also appears in the second season, as well as recurring character Steb, both of whom do not have a credited voice actor. ==Episodes==