Germaine Brée has characterised the struggle of the characters against the plague as "undramatic and stubborn", and in contrast to the ideology of "glorification of power" in the novels of
André Malraux, whereas Camus's characters "are obscurely engaged in saving, not destroying, and this in the name of no ideology". Lulu Haroutunian has discussed Camus's own medical history, including a bout with tuberculosis, and how it informs the novel.
Marina Warner notes its larger philosophical themes of "engagement", "paltriness and generosity", "small heroism and large cowardice", and "all kinds of profoundly humanist problems, such as love and goodness, happiness and mutual connection". Thomas L Hanna and John Loose have separately discussed themes related to Christianity in the novel, with particular respect to and Doctor . Louis R Rossi briefly discusses the role of Tarrou in the novel, and the sense of philosophical guilt behind his character. Elwyn Sterling has analysed the role of Cottard and his final actions at the end of the novel. Father Paneloux has been subject to several literary analyses in the context of faith faced with great suffering. Dr Rieux has been described as a classic example of an idealist doctor. He has also been an inspiration to the life and career of the French doctor Réjean Thomas, and also to the fictional character of Jeanne Dion, starring in the movie trilogy directed by
Bernard Émond (beginning with
The Novena). Perri Klass has noted that at the time of the novel,
sulfa drugs were available for treatment against plague, and has criticised the novel for this historical-medical omission. Journalist
Carlos Maza conducted a critical deep dive into the novel, drawing parallels to the contemporary political climate, including
Trumpism and the
COVID-19 pandemic. ==In the popular press==