The Babinski sign can indicate
upper motor neuron lesion constituting damage to the
corticospinal tract. Occasionally, a pathological plantar reflex is the first and only indication of a serious disease process and a clearly abnormal plantar reflex often prompts detailed
neurological investigations, including
CT scanning of the brain or
MRI of the spine, as well as
lumbar puncture for the study of
cerebrospinal fluid. The phrase "negative Babinski sign" is sometimes used for the normal flexor plantar response.
In infants Infants will usually show an extensor response. In one study of 256 healthy infants, the response to testing was extensor in 73.8%, flexor in 8.9%, and equivocal in 17.3% This extensor response occurs because the
corticospinal pathways that run from the
brain down the
spinal cord are not fully
myelinated at this age, so the reflex is not inhibited by the
cerebral cortex. The extensor response usually disappears – giving way to the flexor response – by 12 months of age. Its persistence beyond age 2–3 indicates a problem in the brain or spinal cord.
Pathways • Afferent:
Nociception detected in the S1
dermatome and travels up the
tibial nerve to the
sciatic nerve to roots of L5,S1 and synapse in the
anterior horn to elicit the motor response. • Efferent: Motor response back through the L5,S1 roots to the sciatic nerve to its bifurcation. Toe flexors are innervated by the tibial nerve. Toe extensors (
extensor hallucis longus,
extensor digitorum longus) are innervated by the
deep peroneal nerve. Loss of normal adult descending pyramidal control of the reflex arc to suppress extensor withdrawal results in the upgoing toes in the plantar reflex known as Babinski's sign. ==Relationship to Hoffmann's reflex==