Prior to the
2013 Knesset elections Tamano-Shata joined the new
Yesh Atid party. Placed 14th on the party's list, she became a Knesset member as the party won 19 seats. She was placed 13th on the party's list for the
2015 elections, but lost her seat as the party was reduced to 11 seats. On 9 February 2018, she returned to the Knesset as a replacement for
Ya'akov Peri, who had resigned following allegations that he had leaked information during a corruption investigation twenty years beforehand. Prior to the
April 2019 elections, Yesh Atid became part of the
Blue and White, with Tamano-Shata placed 24th on the alliance's list. She was re-elected as Blue and White won 35 seats. She was re-elected again in the
September 2019 elections. Following the
March 2020 elections, she was appointed Minister of Aliyah and Integration, also known as Minister of Immigrant Absorption, becoming the first Ethiopia-born minister in the Israeli government. In June 2021 Tamano-Shata was awarded the Magen Begin Prize for Israeli Leadership. After being re-appointed to her ministerial role following the
2021 elections, she resigned from the
Knesset under the
Norwegian Law and was replaced by
Alon Tal. She was re-elected to the Knesset in the
2022 elections. Tamano-Shata spoke at a protest that was held following the 2026
killing of Yimanu Zelka, saying that the attack “shows that something is breaking down in our society.” ==Committee for the Status of Women and Gender Equality==