In the
May 2002 parliamentary election, which was her first election, she stood as the ruling
Lesotho Congress for Democracy (LCD) candidate in the Qacha's Nek constituency, previously held by Prime Minister
Pakalitha Mosisili (who contested the Tsoelike constituency instead), and won 72.4% of the vote. Following the election, in June 2002, she was moved from her position as Minister of Health to that of Minister of Local Government. Following the
February 2007 parliamentary election, she remained in the latter position in the government of March 2007. She was a member of the Qacha's Nek constituency for third time with the win in the elections in 2012 and was appointed the Minister of Local government and Chieftainship Affairs. Sekatle joined the new Pakalitha Mosisili-led splinter party
Democratic Congress on its formation in 2012.{{cite web|title=Lesotho: Jumping Before He's Pushed ==Positions held==