De Rossi's first significant role was as a young and impressionable maid in the Australian
1994 film Sirens. Soon afterward, she moved to Los Angeles and won guest roles on several TV shows and a permanent role in
Nick Freno: Licensed Teacher, before landing a part in the film
Scream 2. During her time in the United States, de Rossi worked to acquire an American accent. De Rossi garnered international attention when she joined the main cast of
Ally McBeal in 1998, playing lawyer Nelle Porter. She remained with the show until its end in 2002. In 2001, she starred in
Who Is Cletis Tout? alongside
Christian Slater. From 2003 to 2006, de Rossi starred as
Lindsay Bluth Fünke on
Fox Television's
Arrested Development. She next portrayed
John F. Kennedy Jr.'s wife,
Carolyn Bessette-Kennedy, in the made-for-TV movie ''
America's Prince: The John F. Kennedy Jr. Story in 2003. That same year, she portrayed an Australian reporter who inspires a protest against Frank Sinatra during a concert tour in The Night We Called It a Day.'' In 2005 de Rossi portrayed Zela, a fortune-teller, in the
Wes Craven thriller
Cursed. From 2007 to 2008, de Rossi appeared in ''
Nip/Tuck's'' fifth season as Julia McNamara's girlfriend,
Olivia Lord. In 2009 and 2010, de Rossi played the high-strung and controlling Veronica Palmer on the ABC show
Better Off Ted. In 2011, she appeared in
Better Off Ted cast member
Malcolm Barrett's music video for "Revenge of the Nerds", spoofing her character in a cameo alongside other cast members of the series. She ranked 69th in ''
Stuff Magazine's
100 Sexiest Women, 31 in Femme Fatales'
Sexiest Women of 2003 list, and 24 in Maxim's
100 Sexiest Women List in 2004; in late 2006, the magazine Blender listed her as one of the hottest women of film and TV. In May 2007, she was featured as one of 100 Most Beautiful in a People special edition. TV Guide'' included her and Ellen DeGeneres in their Power A-List couples in 2007. In February 2012, it was announced that
ABC had ordered a pilot for a new drama series
The Smart One, one of whose executive producers was Ellen DeGeneres, and which featured de Rossi in a leading role. The actress was to star as a "brilliant and successful woman who begrudgingly goes to work for her less-brainy but more popular sister – a former beauty queen, weather girl and now big-city Mayor."
The Smart One was not picked up for the 2012–2013 season. Six years after the series was canceled by Fox, filming for a revived fourth season of
Arrested Development began in August 2012, and de Rossi reprised her role as Lindsay Bluth Fünke. This fourth season consisted of 15 new episodes, which debuted on
Netflix on 26 May 2013. Each episode focused on one particular character, with de Rossi's Lindsay featured in episode 3, "Indian Takers", and Episode 8, "Red Hairing", and also appearing in several other episodes of the season. In July 2014, ABC confirmed that de Rossi was joining season 4 of
Scandal, in the role of Elizabeth North. Her recurring role was upgraded to a series regular for the fifth season. In April 2017, in season six, de Rossi's character was killed off in a golf club attack. De Rossi herself made the decision to depart the series. She is the founder and
CEO of the art company
General Public. == Personal life ==