The work is painted in
oils on a canvas of 259.7 × 194.6 cm. It shows the couple in Lavoisier's office, with a wood-paneled floor and walls of false marble with three classical pilasters. In the center, the couple face the viewer with both their heads in three-quarters profile. Marie-Anne is shown standing, looking at the viewer. Her costume is that in fashion at the end of the 18th century – powdered hair, a white dress with a lace-edged ruffled neckline, and a blue fabric sash. She rests on her husband's shoulder, with her right hand leaning on the table. Antoine Lavoisier is seated, wearing a black vest,
culottes (knee breeches), long stockings, and buckled shoes, a white shirt with a lace
jabot and powdered hair. His face turns towards his wife and he rests his left arm on the table, while writing with his right hand using a
quill pen. The table is covered with scarlet velvet, many papers, a casket, an inkwell with two more quill pens, a
barometer, a gasometer, a water still and a glass
bell jar. A large
round-bottom flask and a tap are on the floor to the right, by the table. To the table's extreme left is a chair with a large document-case and black cloth on it. The document-case, presumed to correspond to Madame's interest in the art of drawing, emphasizes a left-to-right symmetry in the portrait between M. Lavoisier and objects of science visibly displayed on the right, and Madame with her document case of artistic drawings prominently displayed on the left side of the portrait. Significant also is the depiction by David of the wife in a posture physically above the husband, somewhat atypical by late 18th century conventional standards of depicting a married couple in portraiture. The painting is signed at the lower left:
L DAVID, PARISIIS ANNO, 1788. == History ==