•
Abigail Fillmore (née Abigail Powers, 1798–1853), First Lady of the United States •
Abra J. Powers (1883-1971), American lawyer and politician •
Albert E. Powers (1816–1910), American President of Rensselaer Polytechnic Institute •
Ann Powers (born 1964), American writer and pop music critic •
Caleb Powers (1869–1932), US Representative from Kentucky •
Chet Powers (Chester William Powers Jr., 1937–1994), American singer-songwriter •
Claudia Powers (born 1950), American politician •
D. Lane Powers (1896–1968), US Representative from New Jersey •
Darrell Powers ("Shifty" Powers, 1923–2009), American WWII veteran portrayed in
Band of Brothers •
Dave Powers (1932–2008), American television director and producer •
David Powers (1912–1998), Special Assistant to John F. Kennedy •
David B. Powers Jr. (1874–1936), Virginia politician •
David J. Powers (1814–1909), American businessman, co-founder of Whitewater, Wisconsin, and Palmyra, Wisconsin •
Doc Powers (Michael Riley Powers, 1870–1909) an American Major League Baseball player •
Georgia Davis Powers (1923–2016), Kentucky politician •
Gershom Powers (1789–1831), US Representative from New York •
Francis Gary Powers (1929–1977), American pilot who was shot down over the Soviet Union in 1960 •
Hardy Powers (1900–1972), general superintendent in the Church of the Nazarene •
Harold Powers (1928–2007), American musicologist, ethnomusicologist, and music theorist •
Harold J. Powers (1900–1996), Lieutenant Governor of California •
Harriet Powers (1837–1910), African American slave, folk artist and noted quilt maker •
Hiram Powers (1805–1873), American neoclassical sculptor •
Horace Henry Powers (1835–1913), US Representative from Vermont •
J. F. Powers (1917–1999), American short story and novel writer •
Jack Powers (1827–1860), Irish-American gambler and gang leader •
James Powers (New York politician) (1785–1868), New York politician •
James F. Powers (1938–2012), New Hampshire politician •
Jessica Powers (1905–1988), American poet and Carmelite nun •
Jerraud Powers American football player •
Jim Powers (born 1958), American retired professional wrestler •
Joey Powers (1934–2017), American singer-songwriter •
John Powers (American football coach), college football co-head coach •
John Powers (baseball) (1929–2001), baseball outfielder •
John Powers (mayor), American politician, Mayor of Spokane, WA •
John A. Powers (1922–1979), public affairs officer for NASA •
John E. Powers (1910–1998), Massachusetts politician •
John Holbrook Powers (1831–1918), Nebraska pioneer •
John J. Powers (food scientist) (1918–2014), Food Science •
John James Powers (1912–1942), United States Navy officer and Medal of Honor recipient •
John R. Powers (1945–2013), American novelist and playwright •
John Robert Powers (1892–1977), American actor and owner of a modelling agency. •
John T. Powers, President of the Federal League of baseball •
Johnny Powers (1943–2022), originally named Dennis Waters, a Canadian professional wrestler •
Keith T. Powers (born 1992), American actor and model •
Kemp Powers, American playwright, screenwriter, and director •
Kevin Powers (born 1980), American writer and Iraq War veteran •
Kimberly Powers, American epidemiologist •
Kirsten Powers (born 1969), American columnist, blogger, pundit and political commentator •
Lauren Powers (born 1961), American actress, amateur bodybuilder and firefighter •
Leo J. Powers (1909–1967), US Army soldier and a recipient of the Medal of Honor •
Levi P. Powers (1828-1888), Wisconsin legislator and judge •
Lewis J. Powers (1837–1915), Massachusetts businessman and politician •
Llewellyn Powers (1836–1908), Governor of Maine, US Representative from Maine •
Madison Powers, American philosopher •
Mala Powers (1931–2007), American film actress and television guest actress •
Matilde Powers (born 1982), Danish politician •
Megan Powers, Trump campaign worker, former NASA press secretary •
Michelle Powers, American politician •
Mike Powers (disambiguation) •
Millard Powers (born 1965), American musician, songwriter, record producer and recording engineer •
Millard Powers Fillmore (1828–1889), son of US President Millard Fillmore •
Oswald A. Powers (1915–1942), US Navy officer and Navy Cross recipient •
PJ Powers (born 1960), a South African singer also known as Penelope Jane Dunlop and as Thandeka •
Pat Powers (businessman) (1870–1948), Irish-American businessman •
Patrick Powers (volleyball) (born 1958), American volleyball player •
Patrick T. Powers (1860–1925), American minor league baseball executive •
Preston Powers (1842–1904), American sculptor •
Ralph Ernest Powers (1875–1952), American mathematician •
Richard Powers (born 1957), American novelist •
Richie Powers (1930–1998), American professional basketball referee •
Ridgley C. Powers (1836–1912), Governor of Mississippi •
Ron Powers (born 1941), American journalist, novelist, and non-fiction writer •
Samuel L. Powers (1848–1929), US Representative from Massachusetts •
Stefanie Powers (born 1942), American actress and singer •
Stephen Powers (1840–1904), American journalist, ethnographer, and historian of Native American tribes in California •
Thomas Powers (born 1940), American author, intelligence expert, and recipient of the Pulitzer Prize •
Tim Powers (born 1952), American science fiction and fantasy author •
Tom Powers (1890–1957), American stage and film actor •
Victoria Powers (1958–2025), American mathematician •
Warren Powers (1941–2021), American football coach •
Warren Powers (American football) (born 1965), American football player •
William Powers (politician), Chairman of the New York Republican State Committee •
William C. Powers (1946–2019) the 28th president of The University of Texas at Austin •
William T. Powers (1926–2013), scholar of psychology theory •
William T. Powers (industrialist) (1820–1907), manufacturer and capitalist ==Fictional characters with the surname==