Administration of pravadoline on rats showed: • Prolonged the response latency induced by tail immersion in hot water at a temperature of 55 °C (minimum effective dose 100 mg/kg s.c.) • Prevented
hyperalgesia in rats with
brewer's yeast injections during (
Randall-Selitto test) (minimum effective dose 1 mg/kg, p.o.) • Prevented the
nociceptive response induced by paw flexion in the
adjuvant-arthritic rat (ED50 41 mg/kg, p.o.) • Prevented the nociceptive response of
bradykinin-induced head and forepaw flexion (ED50 78 mg/kg, p.o.) The antinociceptive activity of pravadoline cannot be explained by an opioid mechanism, because pravadoline-induced antinociception was not antagonized by naloxone (1 mg/kg, s.c.) and pravadoline did not bind to the
opioid receptors at concentrations up to 10 μM. ==See also==