PRDM12

The human protein isoform is made up of 367 amino acids containing a PR domain (related to the SET methyltransferase domain), 3 zinc fingers, and a C-terminal polyalanine tract. == Function ==

PRDM12 influences the development of nerve cells that assist in perception and sensation of pain, which is an important evolutionary advantage. In humans, mutations in the PRDM12 gene can cause loss of pain perception brought on by defects in the development of sensory neurons. It also has a range of interactions with and affects on various proteins. In vertebrates, PRDM12 directly represses the DBX1 and NKX6 genes. This is thought to be accomplished by utilizing G9a, a strong H3K9 methyltransferase. The indicated result of PRDM12's cross-repressive interaction with the DBX1 and NKX6 genes is that the PRDM12 partially acts as a promoter of V1 interneurons (which are essential to the locomotion of vertebrates). It is a member of the group of PR- domain-containing zinc-finger familyfingers, "which appear to function as negative regulators of oncogenesis and include the tumor-associated genes MDS1-EVI1, RIZ, BLIMP1, MEL1 and PFM1. PRDM12 therefore represents an attractive candidate tumour suppressor gene within the der(9) [derivative chromosome 9] CDR [commonly deleted region]." Several members of the PRDM family are found to be acting as a tumor suppressor or a factor driving oncogenic processes in human diseases, specifically and most notably in solid cancers and hematological malignancies. It is hoped that further study may reveal target genes of PRDM proteins so a greater understanding of the functions of the PRDM family can be achieved. In Xenopus embryos, PRDM12 expression "was partially co-localized with the lateral expression regions" of the SIX1, PAX3, ISLET1, and PAX6 genes, but not those of the FOXD3 and SIX3 genes. In cases where BMP4 was overexpressed, embryos showed an increase in PRDM12 expression. Data indicated that the regulation of PRDM12 expression in Xenopus embryos was controlled by BMP and Wnt signaling. PRDM12 codes for a protein which regulates the neurological path through which pain in perceived, known as PR domain zinc finger protein 12. The protein plays a vital role in the regulation of histone H3-K9 dimethylation. PRDM12's protein also directly affects the development of nerve-endings. The protein is synthesized at the same developmental point as the neurons which sense pain and the growth of the two is linked. == Clinical significance ==

In humans, mutations in the PRDM12 gene can cause loss of pain perception brought on by defects in the development of sensory neurons. There are three different genes that can be mutated to cause CIP. First, a mutation in the SCN9A makes it impossible for nociceptors to respond to harmful stimuli because it causes the gene to lose its function. Past research has shown that PRDM12 is involved in the modification of chromatin. Abnormal functioning of the sensory nerves is what causes the sensory loss in patients with this condition. A third condition that may be caused by a mutation in the PRDM12 gene is Midface toddler excoriation syndrome (MiTES). MiTES is an newly discovered condition that has recently been reported in three children who were unrelated. PRDM12 in particular has been found to play a role in Chronic myeloid leukaemia, which is a clonal stem cell disorder. Researchers mapped the microdeletions and identified a minimal common deleted region. Within this common deleted region was the PRDM12 gene. Because the PRDM family appears to includes tumor suppressor genes and functions as negative regulators of oncogenesis, PDRM12 represents an ideal candidate tumor suppressor gene for chronic myeloid leukaemia. == References ==