Prescott Bush was politically active on social issues. He became involved with the
American Birth Control League as early as 1942, and served as the treasurer of the first nationwide campaign of
Planned Parenthood in 1947. He was also an early supporter of the
United Negro College Fund, serving as chairman of the Connecticut branch in 1951. From 1947 to 1950, he served as Connecticut
Republican finance chairman, and was the Republican candidate for the
United States Senate in the
1950 special election. A columnist in
Boston said that Bush "is coming on to be known as
President Truman's Harry Hopkins. Nobody knows Mr. Bush and he hasn't a
Chinaman's chance." (Harry Hopkins had been one of
Franklin D. Roosevelt's closest advisors.) Bush's ties with Planned Parenthood also hurt him in strongly-Catholic Connecticut, and were the basis of a last-minute campaign in churches by Bush's opponents; the family vigorously denied the connection, but Bush lost to
Sen. William Burnett Benton by only 1,102 votes. Prescott Bush sought a rematch with Sen. Benton in 1952, but withdrew as the Republican party turned to
William Purtell. The death of Senator
Brien McMahon later that year, however, created a vacancy, and this time the Republicans He defeated the Democratic nominee,
Abraham Ribicoff, and was elected to the Senate. A staunch supporter of President
Dwight D. Eisenhower, he served until January 1963. He was re-elected in 1956 with 55% of the vote over
Democrat Thomas J. Dodd (later U.S. Senator from Connecticut and father of
Christopher J. Dodd), and decided not to run for another term in 1962. He was a key ally for the passage of Eisenhower's
Interstate Highway System, Eisenhower later included Prescott Bush on an undated handwritten list of prospective candidates he favored for the 1960 Republican presidential nomination. In terms of issues, Bush often agreed with
New York Governor Nelson Rockefeller. According to
Theodore H. White's book about the 1964 presidential election, Bush and Rockefeller were longtime friends. Bush favored a Nixon-Rockefeller ticket for 1960, and was presumed to support Rockefeller's 1964 presidential candidacy until the latter's remarriage in 1963. Bush then publicly denounced Rockefeller for divorcing his first wife and marrying a woman with whom Rockefeller had been having an affair while married to his first wife. Bush and Representative
John W. McCormack, the Democratic House Majority Leader, co-sponsored the Bush-McCormack Act (Public Law 685), which expedited the construction of local flood-protection works. ==Personal life and death==