Pezzullo began his professional baseball career in 1934, when he played for the
Richmond Colts, an affiliate of the
New York Giants. Pezzullo finished the season fifth in the
Piedmont League in wins, with 16, while finishing fourth on the Colts in games pitched, recording 27 games over the season. He was called "a good pitching prospect" by
Chicago Tribune sports writer
Arch Ward. On November 1 of that year, Pezzullo was traded as a part of a four-man deal that sent him,
Blondy Ryan,
Johnny Vergez,
George Watkins, and cash to the Philadelphia Phillies in exchange for
Dick Bartell. For the 1935 season, Pezzullo, who pitched for the major-league Phillies, recorded a team-worst ERA of 6.40, along with a 3–5 win–loss record over 40 games pitched. He
hit seven batters by a pitch, tying him for the seventh most hit batsmen in MLB. In Pezzullo's final MLB game in 1936, he walked six batters in two innings pitched.
Minor league career Pezzullo also played for two minor league teams during the 1936 season: the Richmond Colts and the
Hazleton Mountaineers. Combined, Pezzullo went 14–10 with a 5.19 ERA. The following season he played for the
Savannah Indians and the Colts; for the Indians, Pezzullo went 13–8 over 165 innings pitched. The following season, he played only for the Indians, an affiliate of the
Pittsburgh Pirates. His 26 wins were best in the
Sally League, while his 288 innings pitched also led all Southern League players. In a game against the
Spartanburg Spartans, Pezzullo struck out 17 batters. After the season, he was sold to the
double-A Toronto Maple Leafs of the
International League, where, under managers
Tony Lazzeri and
Jack Burns, Pezzullo won 11 games and lost 12. He went 5–16 the following year, before leaving the team for the
Syracuse Chiefs and the
Buffalo Bisons in his final year of professional baseball in 1941. ==After baseball==