The protein encoded by this gene acts as a
guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate
RAC1 by exchanging bound
GDP for free
GTP. The encoded protein, which is found mainly in the
cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of
heterotrimeric G proteins. == Clinical significance ==