Princess Nobuko suffered from
brain ischemia in May 2004, which forced her to withdraw for a while to the villa of Sōma family in
Karuizawa,
Nagano Prefecture, for medical treatment and rest. She continued her rest due to
menopause, In 2008, she suffered from
asthma and was repeatedly in and out of the hospital. She underwent long-term medical treatment at the villa of her older siblings, and even after returning to Tokyo, she did not return to the imperial residence, but instead lived in the official residence of the Commissioner of the Imperial Household Agency. In October 2009, she moved from the hospital where she was hospitalized to the Imperial Household Agency building for medical treatment. On the night of 8 September 2019, Princess Nobuko fell at her home in Tokyo. The next morning, due to persistent pain, the Princess went to
Keio University Hospital in Tokyo, where she was diagnosed with a first lumbar vertebral fracture. She was prescribed a total recovery period of 3 months. Princess Nobuko was diagnosed with stage one
breast cancer in November 2022. Doctors expressed no concern about her case, as she had no obvious symptoms of cancer. The Princess was admitted to Keio University Hospital on 16 November for further examinations, and her surgery to remove the tumor was held on 19 November. After undergoing the surgery, which lasted 2 hours, it was discovered that her breast cancer was at stage 0, and not at stage 1. The Princess was discharged from the hospital on 24 November, after doctors confirmed that her recovery was going well and that the chances of cancer recurrence were very low. She received
radiation therapy over 25 sessions at Keio University Hospital between 23 January and 27 February 2023. On 4 March 2024 the Princess underwent surgery for primary angle-closure and
cataracts at Keio University Hospital. == Titles and styles ==