The protein encoded by this gene belongs to the
protein kinase D (PKD) family of
serine/
threonine protein kinases, a subfamily of
protein kinase C. This kinase can be activated by
phorbol esters as well as by
gastrin via the
cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to
diacylglycerol (DAG) in the
trans-Golgi network (TGN) and may regulate
basolateral membrane protein exit from TGN.
Alternative splicing results in multiple transcript variants encoding different isoforms. ==References==