Main •
Tom Payne as Malcolm Bright (né Whitly), a disgraced former
FBI profiler who works for the NYPD. He possesses the unique ability to view crimes from the perspective of the killer, allowing him to pick up on things that other cops might miss. This gift haunts him, causing him to live in a perpetual state of fear that he will one day succumb to the same sociopathic tendencies as his father. •
Aurora Perrineau as Dani Powell, a police detective under Arroyo's command who is sympathetic to Malcolm's difficulties •
Keiko Agena as Edrisa Tanaka, an NYC medical examiner with a romantic interest in Malcolm •
Bellamy Young as Jessica Whitly (née Milton), Malcolm's mother and a businesswoman from an old money high society family, who suffers from
alcoholism as a result of her drinking to cope with her husband's crimes •
Michael Sheen as Martin Whitly, Malcolm's father, a renowned cardiothoracic surgeon, who is incarcerated in an asylum after committing 23 murders as "the Surgeon"
Recurring • Esau Pritchett as Mr. David, a worker at the Claremont Psychiatric Hospital who is in charge of Dr. Whitly •
Charlayne Woodard as Gabrielle Le Deux (season 1), Malcolm's psychologist since his father's arrest •
Molly Griggs as Eve Blanchard (season 1), Malcolm's deceased girlfriend, a lawyer who has an interest in fighting human trafficking •
Dermot Mulroney as Nicholas Endicott (season 1), a pharmaceutical tycoon who has a secret association with Dr. Whitly • Armando Acevedo as Hector • Alan Gary as Burt •
Christian Borle as Friar Pete (season 2), a new patient at the Claremont Psychiatric Hospital •
Catherine Zeta-Jones as Vivian Capshaw (season 2), a resident medical doctor at the Claremont Psychiatric Hospital == Production ==