Fu,
et al. coined the term "pathological angiogenesis" to distinguish between HP59-expressing, and non-HP59-expressing capillaries, however, other researchers have not used this terminology. CM101 has been shown in a published Phase I, FDA-approved clinical trial under IND to have clinical safety and effectivity on select
stage IV cancer patients, specifically targeting tumor vasculature HP59 is expressed in the adult in wound healing, and in tumor angiogenesis, as shown in mice. The gene for HP59 contains, entirely within its coding region, the
Sialin Gene
SLC17A5 (Solute carrier family 17 (anion/sugar transporter). Member 5, also known asSLC17A5 or sialin is a lysosomal membrane
sialic acid transport protein which in humans is encoded by the SLC17A5 gene on Chromosome 6, and appears to be important in CNS myelination. HP59 has a transcription initiation site 300bp upstream of the initiation site for the Sialin Gene SLC17A5, and encodes 41 additional aminoacids at the Amino-terminal. == References ==