Protase Rugambwa was born on 31 May 1960 at Bunena, in the
diocese of Bukoba. He had an elder brother, Paulo Kishumba (1957-2021). He was given the name "Rugambwa" after
Laurean Rugambwa, who had become Tanzania's first cardinal a few weeks earlier. After attending primary and secondary schools and Minor Seminary Katoke Itaga, Rugambwa studied philosophy at Kibosho Senior Seminary and theology at St. Charles Lwanga Segerea Senior Seminary. He was parish vicar of Mabira for 1990-91. He taught at the Minor Seminary of Katoke from 1991 to 1994, with responsibility for the liturgy and serving also as chaplain of Biharamulo hospital. From 1994 to 1998 he pursued a doctorate in pastoral theology at the
Pontifical Lateran University. Returning to Tanzania, he was spiritual director of seminarians and director of vocations for the Diocese of Rulenge and executive director of the pastoral care department for 1998-99. From 2000 to 2002 he was
Vicar General of the diocese of Rulenge and moderator of personnel. He worked in Rome on the staff of the Congregation for the Evangelization of Peoples from 2002 to 2008. He received his episcopal consecration on 13 April Pope Francis confirmed him as adjunct secretary on 21 September 2013. On 9 November 2017,
Pope Francis promoted him to secretary of the Congregation. On 13 April 2023, Pope Francis named him archbishop coadjutor of Tabora. On 9 July 2023, Pope Francis announced the plans to make him a cardinal at a consistory scheduled for 30 September. At that consistory he was made cardinal priest of
Santa Maria in Montesanto. On 10 November 2023, he became archbishop of Tabora upon the resignation of
Paul R. Ruzoka. He participated as a
cardinal elector in the
2025 papal conclave that elected
Pope Leo XIV. ==Publication==